Irrfan Khan, best known worldwide for roles in "Slumdog Millionaire" and "Jurassic World," died at age 53.
The Bollywood star had died in a hospital in Mumbai's western city, his agency said.
The actor posted on Twitter in 2018 saying he'd been diagnosed with an endocrine tumor, a rare disease that affects cells that release hormones into the bloodstream.
He subsequently received treatment at a hospital in London and recovered well enough to shoot "Angrezi Medium," the film that would turn out to be his last.
It was due to release last month but was cut short due to pandemic coronavirus.
His breakthrough role came in 2002's "The Warrior," chosen for the prestigious San Sebastian film festival and winning a Bafta for Best British Film.
He continued to be successful in Indian mainstream movies including "Maqbool," an adaptation of Shakespeare's "Macbeth" set in the Mumbai underworld.
More Bollywood roles followed, like "Rog" and the "Life In A ... Metro" musical.
The actor was best known as the police inspector in "Slumdog Millionaire" to English-speaking audiences, which went on to win eight Oscars.
He also starred in Hollywood's big-budget productions including 'The Amazing Spider-Man' (2012), 'Jurassic World' (2015) and 'Inferno' (2016).
He played the adult version of the lead character in Ang Lee's Oscar-winning "Life of Pi" in 2012. A spokesman said in a statement: "'I trust, I've surrendered;' these were some of the many words Irrfan expressed in a heartfelt note he wrote in 2018 opening up about his cancer fight. And a man of few words, with his deep eyes and his memorable actions on screen, and an actor of silent expressions.
"It's saddening that we have to bring forth the passing news of him this day. Irrfan was a strong soul, somebody who fought till the very end and inspired everybody who came near him.
"We are all praying and we hope he will be at peace. And to resonate and part with his words he said, 'As if for the first time I were tasting life, the magical side of it.'" He is survived by his wife Sutapa Sikdar, and sons Babil and Ayan.