Leaders Bayern Munich, chasing an eighth successive title, will host 13th-placed Eintracht Frankfurt on Saturday night, while in the afternoon Borussia Dortmund, four points behind, will visit sixth-placed VfL Wolfsburg.
The restart last week was generally seen as having gone off successfully, although at any of the games in a surreal atmosphere without spectators.
At least half a dozen players have suffered injuries, however, highlighting concerns about plunging straight into competitive action following a two-month stop without warm-up matches.
The most conspicuous was midfielder Giovanni Reyna, a seventeen-year-old from the United States, who was denied a first start for Borussia Dortmund because of an injury during the warmup when they faced Schalke 04 in the Ruhr derby.
He was replaced by Thorgan Hazard who, while Schalke 04 pair Jean-Clair Todibo and Amine Harit also suffered injuries, left himself with an injury during the 4-0 win.
Other injuries included Hoffenheim's Sebastian Rudy and Ihlas Bebou, Marcus Thuram of Borussia Moechengladbach and Hertha Berlin's Per Ciljan Skjelbred.
Even though teams can now make five substitutions per match instead of the usual three - a temporary measure brought in especially to deal with the unusual circumstances - the upcoming flurry of fixtures leaves players even more vulnerable.
A midweek round of matches next week means teams will play three times over a period of 10 days.
"After 60 minutes the players will be flat," warned earlier this month Marc Lorenz, a midfielder with second tier Karlsruher. "Even the five replacements which were made will not help. That's when the tiredness comes and then the serious injuries.
"Many play for a new contract," he added. "If a cruciate ligament is teared by one of them, no one signs it. Health is invaluable.'
The next ten days will show if his fears are unfounded, or not.
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